Alternative Splicing and Disease - Progress in Molecular and Subcellular Biology - Philippe Jeanteur - Books - Springer-Verlag Berlin and Heidelberg Gm - 9783540344483 - August 3, 2006
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Philippe Jeanteur
Alternative Splicing and Disease - Progress in Molecular and Subcellular Biology 2006 edition

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Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

Marc Notes: Includes bibliographical references and index. Jacket Description/Back: Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. Table of Contents: Methods and Platforms for the Quantification of Splice Variants' Expression.- Pre-mRNA Missplicing as a Cause of Human Disease.- Alternative Splicing: Therapeutic Target and Tool.- SR Proteins as Potential Targets for Therapy.- Misregulation of Tau Alternative Splicing in Neurodegeneration and Dementia.- Spinal Muscular Atrophy and Therapeutic Prospects.- Misregulation of Alternative Splicing Causes Pathogenesis in Myotonic Dystrophy.- Redirecting Splicing to Address Dystrophin Mutations: Molecular By-pass Surgery.- Altered Splicing in Prelamin A-Associated Premature Aging Phenotypes.- Splicing Modulation as a Modifier of the CFTR Function.

Media Books     Hardcover Book   (Book with hard spine and cover)
Released August 3, 2006
ISBN13 9783540344483
Publishers Springer-Verlag Berlin and Heidelberg Gm
Pages 257
Dimensions 155 × 235 × 18 mm   ·   557 g
Language French  
Editor Jeanteur, Philippe

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